Pyoderma gangrenosum (PG), hidradenitis suppurativa (HS), and the spectrum of the associated autoinflammatory syndromes, including pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome, PSTPIP1‐associated myeloid‐related proteinemia inflammatory (PAMI) syndrome, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH) syndrome, and pyogenic arthritis, pyoderma gangrenosum, acne, and suppurative hidradenitis (PAPASH) syndrome, are debilitating dermatological disorders characterized by chronic inflammation and tissue damage. Here, PSTPIP1 is linked to bacterial arthritis.