The PG lesion of PASH syndrome patients shows significantly elevated levels of inflammatory cytokines and mediators, including IL‐1β, TNF‐α, IL‐17, IL‐8, MMP‐2, and MMP‐9, compared to healthy skin.19, 83. The gene discussed is IL1B; the disease is Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome.