For example, an animal study which examined the impact of ablation of IL‐1 receptor 1 (IL‐1R1), in conjunction with diet‐induced obesity during pregnancy showed that not only was there no benefit for the IL‐1R1−/− mice, but their metabolic health worsened both during pregnancy and the postpartum period compared to their wild‐type counterparts (Plows et al., 2021). This evidence concerns the gene IL1R1 and obesity due to melanocortin 4 receptor deficiency.