When analyzing the proportions of CD4+, CD8+, CD4+CD8+ (DP), and CD4−CD8− (DN) T cells (Figure 4B–E), there were significant differences between control and SLE mice in the percentages of DN T cells and CD4+ T cells (DN T cells: Pstrain<0.0001, CD4+ T cells: Pstrain<0.0001). Here, CD4 is linked to systemic lupus erythematosus.