DeBosch’s group has recently investigatedthe effects of trehalose glycopolymers on hepatocyte CD53 blockingin basal and overnutrition contexts, which may be an effective wayto reduce diseases that combine overnutrition and inflammation, suchas NASH and type 2 diabetes.33 It is believedthat free trehalose blocks carbohydrate uptake into hepatocytes asa nonselective inhibitor of GLUT.27 Therefore,the question arises whether polymers containing pendant trehalosecan also block GLUT. Here, CD53 is linked to overnutrition.