HTT and Huntington disease: Some of them arealso able to disintegrate preformed mature amyloid fibrils into smallerparts.67,71In vitro studies on themodel neuronal cell line for HD (HD150Q) have proved that the poly(trehalose)nanoparticles have high cellular uptake,67−71 as well as inhibit the intracellular aggregationof mutant huntingtin protein inside these cells,67−70 and can strongly outperform freetrehalose and trehalose-absent nanoparticles (if studied).