Chen’sgroup has developed trehalose-loaded mSiO2@MnOx-mPEG nanoparticlesfor autophagy-enhanced cancer-cell ferroptosis.32 The dual mechanism of action of nanoparticlesstarts by inhibiting GPX4 (glutathione peroxidase 4)-induced ferroptosisin cancer cells due to the high glutathione (GSH) consumption efficiencyof nanoparticles. Here, GPX4 is linked to cancer.