Induction of ferroptosis is a prospective strategy for treatment‐resistant of tumors including prostate cancer.[32] Emerging evidence has suggested that factors in microenvironment, such as metabolites and EVs, can activate antioxidant mechanisms and suppress ferroptosis in tumor.[16, 33] In this study, we found that taurine, a metabolite of TAM, could effectively inhibit ferroptosis in PCa by activating the LXRα/SCD1 aixs. Here, NR1H3 is linked to prostate carcinoma.