In order to evaluate the function of M2 type macrophages on prevention of PCa from ferroptosis, THP‐1‐derived M0 type macrophages (Figure S1A,B, Supporting Information) were first induced to become M2 macrophages, which was confirmed by upregulated expression of M2 macrophage markers including ARG1, CD163, and IL‐10 (Figure S1C,D, Supporting Information). This evidence concerns the gene CD163 and posterior cortical atrophy.