Further, inhibition of CP-CML CD34+ cells showed an upregulation of self-renewal gene (CKIT, PBX1, HOXA6, FOXH1, MEIS1). This upregulation could be the result of targeting progenitor cells [48] and the consequent selection for more primitive cells that entered a quiescent state to prevent apoptosis [7, 49]. Here, PBX1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.