VEGFA and diabetes mellitus: Based on the results of KEGG pathway, HYD may treat diabetes through multiple pathways, such as MAPK signaling pathway, PI3K-AKT signaling pathway, endocrine resistance, EGFR tyrosine kinase inhibitor resistance, regulation of lipolysis in adipocytes, VEGF signaling pathway, etc. The PI3K/AKT signaling pathway is crucial in cellular physiology as it helps transmit growth factor signals during organismal growth and essential cellular processes.