The sEVs-encapsulated GQDs/Cy5-miR exhibited efficient cellular uptake and endosomal escape, and significant tumor accumulation and inhibition due to the enhanced delivery of functional miR-193a-3p that binds to its target gene CCND1. Simultaneously, the fluorescent tag in GQDs/Cy5-miR enabled in vivo visualization of tumor therapeutics as the binding between miR-193a-3p and its target gene CCND1 occurred. This evidence concerns the gene CCND1 and neoplasm.