Cochran’s Q test showed no evidence for heterogeneity, and MR-Egger intercept analysis did not indicate any horizontal pleiotropy for the IVs (PCochran’s Q = 0.669 and Pintercept = 0.766 for the IL-18-SLE association; PCochran’s Q = 0.905 and Pintercept = 0.215 for the IL-18-IBD association). This evidence concerns the gene IL18 and inflammatory bowel disease.