Among them, LAMP2, GRIA3, PHF6, and HPRT1 genes are associated with Danon disease (300,257), Intellectual deficiency, X-linked syndrome, Wu type (300,699), BFL syndrome (301,900), Lesch Nyhan syndrome (300,322) and other syndromes. The gene discussed is HPRT1; the disease is Lesch-Nyhan syndrome.