Interestingly, increasing studies identified that 5-Aza-CdR effectively inhibits atherosclerosis development in several well-established animal models of atherosclerosis, including diet-induced atherosclerosis in ApoE−/− mice, LDLr−/− mice, and ApoE−/− mice undergoing carotid partial ligation [104–106]. The gene discussed is APOE; the disease is atherosclerosis.