MMP8 rs3740938 contributed to an increased predisposition to CRC under the codominant (p = 0.044, OR = 1.31, 95% CI: 1.04–1.64), dominant (p = 0.013, OR = 1.31, 95% CI: 1.06–1.63) and log-additive (p = 0.017, OR = 1.24, 95% CI: 1.04–1.47) models. This evidence concerns the gene MMP8 and colorectal carcinoma.