The results demonstrated proliferation (Fig. 8A and B) and migration (Fig. 8E-H) abilities of HT-29 and SW480 cells, whether or not to overexpress CXCL3, were significantly reduced following treatment with 100 μΜ PD98059, suggesting an involvement of ERK1/2 pathway in the malignant process of COAD. Here, CXCL3 is linked to colon adenocarcinoma.