CCND1 and neoplasm: For example, Fan et al. revealed a possible cooperation of Cyclin D1 with ERK, they found that overexpresion of NEK2 resultes in the upregulation of Cyclin D1 in a MAPK/ERK-dependtent manner, upon with tumor cells tumor the ability to regulate the process of cell mitosis, and eventually leads to increased proliferative response [33].