CXCL3 and colon adenocarcinoma: The results showed that the inhibition rates exerted by PD98059 on CXCL3-overexpressing cell proliferation (Fig. 8C and D) and migration (Fig. 8I and J) were surprisingly enhanced compared with their mock control cells, indicating the contribution of CXCL3 to the pathogenesis of COAD via an ERK-dependent mechanism.