WNK2 and cancer: Although the current study did not detect the effect of CXCL3 on the proliferation and migration of normal colon cells, we have confirmed in previous study that CXCL3 also exerts proliferative and migration-promoting roles on non-tumor cells [11], suggesting that CXCL3 has not a specific role in tumor cells.The mechanisms underlying the tumor process are related numerous signal pathways, in which mitogen activated protein kinase (MAPK) signal pathway is essential for the growth and diffusion of human cancer cells [22].