Recently, it has been increasingly recognized that CXCL3 appears to enhance tumor angiogenesis and has a key role in tumor cell growth, migration, invasion, and metastasis through several mechanisms, including inducing calcium mobilization and ERK1/2 phosphorylation, inhibiting the activation of adenylate cyclase activator, and reducing the generation of cyclic adenylate [19]. This evidence concerns the gene MAPK3 and neoplasm.