As shown in Fig. 1A-B, there was no significant difference in the expression of NLRP3 between breast cancer tissue and adjacent normal tissue parenchyma cells (Fig. 2A); While, dramatically tumor immune-stromal overexpression of NLRP3 (x2=11.130, P=0.001; Fig. 2B) was found in breast cancer tissues. This evidence concerns the gene NLRP3 and neoplasm.