Regarding NTRK2, most immune checkpoint signatures (CD274, CTLA4, IDO1, PDCD1LG2, LAG3, TIGIT, PDCD1, and HAVCR2) were mildly lower in NTRK MT NSCLC than in NTRK WT NSCLC (Fig. 5G). This evidence concerns the gene TIGIT and non-small cell lung carcinoma.