Similar findings were obtained, with most immune-related signatures in NTRK1 MT NSCLC being equivalent (CD274, CTLA4, IDO1, LAG3, TIGIT, and PDCD1) or even more abundant (GZMA, PRF1, CXCL9, and CXCL10) compared with those in NTRK1 WT NSCLC (Fig. 5F). Here, TIGIT is linked to non-small cell lung carcinoma.