Previously, a significant association between markers in interferon regulatory factor 6 (IRF6), Wnt family member 3 A (WNT3A), and bone morphogenetic protein 5 (BMP5) genes among orofacial cleft and tooth agenesis was found; however, variants of Fas-associated factor 1 (FAF1) and grainyhead-like transcription factor 3 (GRHL3) genes contributed only to craniofacial development [9–12]. Here, GRHL3 is linked to tooth agenesis.