Therefore, in this systematic review and meta-analysis of randomized clinical trials (RCTs), our aim is to investigate and clarify the potential benefits in terms of PFS, OS, and safety when utilizing PD-1/PD-L1 inhibitors in combination with carboplatin and paclitaxel chemotherapy, as compared to using carboplatin plus paclitaxel chemotherapy alone, in patients with advanced or recurrent endometrial cancer. This evidence concerns the gene PDCD1 and endometrial cancer.