IGHE and asthma: A single-centre Japanese study investigating the characteristics of children with asthma exacerbations before the COVID-19 pandemic found that the median WBC count and total IgE level were 12,000/μL (range, 3,400–32,800/μL) and 207 IU/mL (range, 4–11,800 IU/mL), respectively, and the exacerbation attacks were regarded as mild in 21/216 (10%), moderate in 146/216 (68%), and severe in 49/216 (22%) patients [26].