CRP and cancer: Inflammation is one of the hallmarks of cancer, and the pro-inflammatory effects of markers of systemic inflammatory response (SIR) that often reflect cancer immune status, such as plasma C-reactive protein (CRP), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR), have been shown to play an important role in the development and progression of cancer.