Bifidobacterium, the dominant member of gut probiotics microbiome, reduces the risk of intestinal infections by regulating immune responses and protecting against intestinal barrier dysfunction [32], which protects against cancer by downregulating EGFR and COX-2 [31, 33] and induces apoptosis in cancer cells via the activation of pro-apoptotic Bax and the inactivation of the anti-apoptotic Bcl-2 proteins [34]. This evidence concerns the gene BCL2 and cancer.