Thus, while CDC20 has been implicated as a cancer-driving gene with higher levels often associated with melanoma metastases and poorer survival, we posit that specific levels of CDC20 expression may be crucial to supporting or allowing passage of melanocytes through malignant transformation (CDC20 low) to locally invasive cancer and then on to metastatic disease (CDC20 high, Fig. 5e). The gene discussed is CDC20; the disease is melanoma.