CTCF and melanoma: In order to evaluate for enrichment of putative TF binding site motifs, we used Homer analysis of pMRRs which identified motifs for TFs known to play prominent roles in melanoma, including SOX1018,44,45 (p-value = 1 × 10−472) and ETS family factors46, as well the multifunctional chromatin regulator CTCF (p-value = 1 × 10−6092, Supplemental Fig. 1a).