CDC20 and melanoma: CDC20 promoter variants lead to a decrease in reporter activity; however, tumors with relatively higher levels of CDC20 have worse overall survival (Supplemental Fig. 1) and CDC20 has been shown to be essential for migration in melanoma mouse models57.Therefore, we hypothesize the existence of both a CDC20-low and CDC20-high phenotype that may support specific transcriptional programs associated with key melanoma phenotypes, as is known with MITF15,58,59.