To begin probing for the potential existence of a CDC20-high and CDC20-low state, we utilized three cohorts of bulk RNA-sequencing on melanoma tumors: (1) Kunz et al. (2018) cohort of 23 nevi and 57 primary melanomas, (2) TCGA-SKCM, and (3) ICGC-MELA. This evidence concerns the gene CDC20 and melanoma.