IFNG and viral infectious disease: Alveolar macrophages and infiltrating immune cells are thought to be the major source of IL-626, but our finding that poly(I:C)-induced IL-6 production in bronchial epithelial cells is enhanced by IFN-γ priming may be important for understanding the mechanism of cytokine overproduction associated with the exacerbation of viral infections, such as SARS-Cov-2 and influenza.