IFNG and COVID-19: Patients with severe COVID-19 have been reported to have hyperinflammatory conditions caused by the excessive and uncontrolled release of proinflammatory cytokines such as interleukin-1 (IL-1), IL-2, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IFN-inducing protein 10 kDa (IP10), and granulocytes-colony stimulating factor4,5.