Like Spink1, the preferential overexpression of Elf3 in the CD133+ cells and also in the HCC tumor bulk in both proto-oncogene driven and inflammation-associated HCC tumor models was also apparent, while Elf3 expression was not altered or at a much lesser extent in the regenerating liver (Supplementary Fig. S4b, c). This evidence concerns the gene ELF3 and hepatocellular carcinoma.