GPNMB and neoplasm: Differential gene expression showed an enrichment of genes involved in T cell recruitment (CXCL9, CXLC10) and interferon-gamma activity (GBP1, STAT1) in the macrophage compartment of responding tumours, while non-responders were enriched in immunosuppressive markers (GPNMB, CCL18; Fig. 5b).