SPON2 and neoplasm: Although both CD8 TEX and CD8 TEMRA contained clonally-expanded T cells, it was the CD8 TEMRA, that were more abundant in the pre-treatment TME of responding tumours and found typical CD8 TEMRA genes (CX3CR1, SPON2 and FCGR3A) to be overexpressed in intra-tumoural T cells from responders compared to non-responders.