First, comparing relative abundancies of various T cell phenotypes in the TME between responders and non-responders, we found that CD8 TEMRA were more abundant in responding tumours (p = 0.04), while CD8 TEM were increased in non-responders (p = 0.005; Fig. 2e; Supplementary Fig. 3c). The gene discussed is CD8A; the disease is neoplasm.