In order to identify those CD8 T cells phenotypes associated with response to atezo/bev, we compared several characteristics of the tumoural and peripheral immune system between responders and non-responders, including i) abundancies of intra-tumoural CD8 T cells, ii) the tumoural and peripheral TCR repertoire and iii) the degree of TCR sharing between tumour and blood. This evidence concerns the gene CD8A and neoplasm.