HDAC8 and melanoma: A Kyoto Encyclopedia of Genes and Genomics (KEGG) pathway analysis revealed that HDAC8 expression increased enrichment for pathways important for melanoma migration including PI3K-AKT signaling, Focal Adhesion, ECM-Receptor Interactions, Regulation of Actin Cytoskeleton, MAPK signaling and RAP1 signaling (Fig. 2b) while decreasing enrichment of some Metabolic Pathways, including glutathione and purine metabolism (Fig. 2c).