Immunoblot profiling of a melanoma cell line panel demonstrated that higher expression of the melanocyte lineage transcription factor MITF correlated with lower HDAC8 expression and reduced levels of signaling molecules known to be regulated by HDAC8 including acetylated SMC3, EGFR (both total and phospho) and c-Jun (both total and phospho)20,21 (Fig. 1a). Here, HDAC8 is linked to melanoma.