They are overall positive with over 60% of the clinical and biochemical measures, including eGFR as noted above, multiple serum amino acids, serum triglycerides, glycaemic traits, lactate, pyruvate, inflammation (CRP and GlycA), liver function markers [alkaline phosphatase (ALP), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT)], various obesity measures, blood pressure and the FINRISK cardiovascular disease (CVD) and the Chien chronic kidney disease (CKD) risk scores. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.