They are overall positive with over 60% of the clinical and biochemical measures, including eGFR as noted above, multiple serum amino acids, serum triglycerides, glycaemic traits, lactate, pyruvate, inflammation (CRP and GlycA), liver function markers [alkaline phosphatase (ALP), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT)], various obesity measures, blood pressure and the FINRISK cardiovascular disease (CVD) and the Chien chronic kidney disease (CKD) risk scores. This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.