The authors divided the mouse models of cSCC into 4 groups of 5 mice each and gave PD-1 Abs+OE-NC, PD-1 Abs+HPV vaccine+OE-NC, PD-1 Abs+OE-METTL3, and PD-1 Abs+HPV vaccine+OE-METTL3 treatments respectively. This evidence concerns the gene METTL3 and skin squamous cell carcinoma.