In the combination of anti-PD-1 antibody and HPV vaccine, tumor volume and weight were significantly reduced, and co-treatment with HPV vaccination and anti-mouse PD-1 antibody resulted in complete inhibition of tumor growth, while the inhibitory effect of anti-PD-1 antibody on tumor volume and weight was attenuated after overexpression of mettl3 (Fig. 9A‒C). This evidence concerns the gene METTL3 and neoplasm.