PNPLA2 and neoplasm: To unravel the mechanism by which DOX + 4μ8C shifts the triacylglycerides between tumor and surrounding non-tumoral tissue, the mRNA-expression of key enzymes involved in lipophagy (lysosomal acid lipase, LAL), de novo lipogenesis (fatty acid synthase, FAS; and glycerol-3-phosphate acyltransferase-1, GPAT-1), lipolysis (adipose triglyceride lipase, ATGL; and monoacylglycerol lipase, MGL) and fatty acid oxidation (PPARα) were measured (Table 1 and Figure 5D–G).