Even without direct evidence illuminating detailed pathways linking VTE and excessive risk of cardiovascular comorbidities, this study revealed some proteins, such as genetically predicted levels of LRP12, prothrombin, ANGPT1, LRP4, and IL-6 sRa, shared by etiologies of VTE and other cardiovascular diseases, which may provide clues for cardiovascular risk management among patients with VTE. Here, LRP4 is linked to cardiovascular disorder.