Thirty of 38 combinations were related to obesity indicators, and 5 proteins (annexin II [Annexin A2], coagulation FXI, Kininostatin-1, LRP12, and prekallikrein [plasma kallikrein]) showed consistent mediation effects on the associations of 3 obesity indicators with VTE risk (Figure 4A). Here, KLK4 is linked to obesity due to melanocortin 4 receptor deficiency.