Very recently, an in vitro biophysical study focused on examining the impact of three ALS-causing hPFN1 mutants on the dynamics of phase-separated droplets of FUS NTD (1-267), followed by further high-resolution NMR characterization of the conformations and dynamics of both the hPFN1 mutants and FUS NTD [41]. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.