Hv1 was expressed in microgliaThe level of microglial Hv1 expression has species differences, Hv1 currents are much larger in mice than in ratsPresence of Hv1 protein and Hv1 current in cultured human microgliaActivating Hv1 leads to NOX-dependent ROS production in brain microglia. ROS production is significantly attenuated in Hv1-/- mice, and Hv1-/- mice are protected from NOX-mediated neuronal death and brain damage after stroke. This evidence concerns the gene HVCN1 and Stroke.