HVCN1 and Parkinson disease: The mRNA expression of HVCN1 in the brains increased in PD patients, especially in male PD patientsHv1 knockout showed the neuroprotective effects and decreased pro-inflammatory cytokine levels and pro-oxidant factors both in MPTP and LPS Parkinson’s disease modelsIn primary microglial cultures, with LPS treatment increasing Hvcn1 mRNA levels and Hv1-/- microglia failing to exhibit the LPS-mediated inflammatory responseConditioned media from Hv1-/- microglia treated with LPS resulted in an attenuated loss of cultured dopamine neuron cell viability