In mouse model of cuprizone-induced demyelination, a model for MS, Hv1-/- mice are partially protected from demyelination and motor deficits compared with those in WT mice, which is accompanied by reduced ROS production, ameliorated microglial activation, increased oligodendrocyte progenitor cell (NG2) proliferation, and increased number of mature oligodendrocytes. The gene discussed is HVCN1; the disease is myeloid sarcoma.