HVCN1 and glycogen storage disease VI: In physiological conditions, microglia and BMDM express Hv1 with the highest level among glial cells, and upregulation of Hv1 in microglia/macrophages is presented in multiple injuries and diseases of the CNSMyelin debris accumulation occurs in both the focal lesion and the site where neurodegeneration takes placeBoth genetic deletion of the Hv1 in vitro and neutralization ofHv1 with antibody in the brain in vivo promotes the migration of microglia/macrophagesNeutralization of Hv1 with antibody in the brain in vivo promotes myelin debris clearance by microglia/macrophages