Earlier studies have shown that plasma MMP-9 concentrations may be a useful prognostic marker in septic shock (Nakamura et al., 1998), TIMP-1/MMP-9 ratio is correlated with sepsis severity and coagulation index, and may be a new biomarker of sepsis outcome (Lorente et al., 2014). The gene discussed is TIMP1; the disease is Sepsis.