Some researchers have reported that IL-6 mediated cardiac inflammation and dysfunction in a burn plus sepsis model [27], and the inhibition or blockage of IL-6 was supposed to be a treatment for sepsis [28], while others suggested that IL-6 activates neutrophils to enhance the killing of bacteria to improve the survival rates of sepsis patients [29], and the loss of IL-6 signaling led to impaired monocyte/macrophage killing of pathogens, which could be reversed by IL-6 supplementation [30]. The gene discussed is IL6; the disease is Sepsis.