The following regulatory mechanisms exist for EGFR and NHE3 in porcine transmissible gastroenteritis virus (TGEV), which is also an alphacoronavirus: infection with TGEV enhances intestinal glucose uptake and increases the expression of EGFR, SGLT1, and GLUT2 in intestinal epithelial cells, and there is a positive regulatory relationship between EGFR and SGLT1 (Ren et al., 2013; Dai et al., 2016). This evidence concerns the gene SLC5A1 and infection.