To examine this hypothesis, wildtype (Cish+/+) and CISH knockout (Cish−/−) mice were compared in mouse models of malaria anemia (Craig et al., 2012) or experimental cerebral malaria (ECM) (de Oca et al., 2013) resulting from elevated pro-inflammatory immune responses (Hanum et al., 2003). This evidence concerns the gene CISH and cerebral malaria.