PTGIR and atherosclerosis: Moreover, various disease models have highlighted the implications of these lipid-like GPCRs in the pathophysiology of conditions such as obesity and diabetes (GPR119), colitis (S1PR4, PTGER4, PTGIR), autoimmunity (GPR132) and atherosclerosis (GPR132, PTGIR) (Aleti et al., 2023).