Moreover, various disease models have highlighted the implications of these lipid-like GPCRs in the pathophysiology of conditions such as obesity and diabetes (GPR119), colitis (S1PR4, PTGER4, PTGIR), autoimmunity (GPR132) and atherosclerosis (GPR132, PTGIR) (Aleti et al., 2023). Here, PTGIR is linked to diabetes mellitus.