PCSK9 and coronary artery disorder: It is noteworthy that GOF PCSK9 mutations, which initially served as a key discovery in understanding the role of PCSK9 in DLP, including FH (9) subsequently took a backseat to LOF mutations (10), despite their rare occurrence - about 1.5-2.5% in the population (11, 12), and thus their infrequency in HeFH with CAD.