NOS3 and diabetes mellitus: Multiple peroxisome proliferator activator receptor (PPAR) agonists (eg, cilostazol, GW0742, pioglitazone, pemafibrate, and fenofibrate) stimulate ischemic angiogenesis and/or prevent capillary regression in rodent models of hindlimb ischemia and diabetes.40,41,42,43,44,45,46 These agents induce angiogenic stimulators including VEGFA and endothelial nitric oxide synthase (eNOS) in the ischemic muscle tissue.