AHR expression is increased in skeletal muscle in association with chronic kidney disease and murine hindlimb ischemia or PAD, and muscle-specific deletion of AHR improves muscle reperfusion, mass, and function.74 Notably, endothelial-specific AHR overexpression impairs ischemic angiogenesis in murine hindlimb ischemia.75 Therefore, AHR is a negative regulator of vascular regeneration. The gene discussed is AHR; the disease is peripheral arterial disease.