Cardiac lymphangiogenesis occurs in ischemic heart disease during the acute and chronic phases.20 In the acute phase of MI, the expression of VEGFR-3 protein near the infarcted region is increased, as is the density of lymphatic vessels.30 This endogenous response of the cardiac lymphatics facilitates an optimal immune cell load that is necessary for effective tissue repair.31,32,33 However, this increase is limited to certain pathological areas, such as necrotic margins, scars, and reactive pericarditis. Here, FLT4 is linked to myocardial infarction.