Interestingly, the mutation of Flt4 in CHD is different from the mutation of Flt4 in Milroy’s disease.66 This indicates that VEGFR-3 is not limited to LECs during embryonic development; therefore, its role goes beyond regulating lymphangiogenesis.66 The relation between cardiac lymphangiogenesis and CHD needs to be further explored. Here, FLT4 is linked to Milroy disease.