Antisense non-coding RNA in the INK4 Locus (ANRIL) is transcribed from human chromosome 9p21,36 a susceptibility locus of coronary artery disease now considered the most robust genetic marker of atherosclerotic cardiovascular disease, including PAD.37 Intriguingly, linear isoforms of ANRIL are associated with increased atherosclerosis susceptibility and an elevated risk of atherosclerotic plaques. This evidence concerns the gene CDKN2B-AS1 and coronary artery disorder.