MALAT1 and Atherosclerotic lesion: Inhibition of MALAT1 in mice reduced blood flow recovery in femoral artery ligation-induced hindlimb ischemia (HLI), a mouse model of PAD.24,25 A global knockout of MALAT1 induced similar results, hypothesized to be mediated through vascular endothelial growth factor receptor 2 binding.26 Moreover, reduced MALAT1 levels were found in human atherosclerotic lesions of symptomatic patients, associated with a poor prognosis.