CDKN2B-AS1 and myocardial ischemia: In fact, ANRIL overexpression was shown to increase eNOS expression and promoted post-ischemic angiogenesis while improving cardiac function in mice following myocardial ischemia.42 ANRIL is not conserved in mice, but deficiency of CDKN2B, a gene found in the 9p21 locus, showed increased tissue necrosis and reduced blood flow in mice undergoing HLI.43