MALAT1 and diabetes mellitus: In macrophages, MALAT1 was found to enhance the biological functions of high glucose-impaired macrophages, leading to improved phagocytosis, a shift towards a pro-healing phenotype, reduced apoptosis, and thus ultimately promoting the healing of diabetic wounds.27 However, another study concluded MALAT1 overexpression increased inflammation and EC dysfunction in diabetes.28 Thus, while it is clear that MALAT1 is involved in EC function and vascular repair, the effect of its modulation may be more context-dependent.