Analysis of RNA-seq datasets from brains of AD patients versus age-matched healthy individuals showed that expression of mitochondrial import genes was decreased with AD (Sorrentino et al., 2017), consistent with the observed decrease in expression of Tom20 and Tom70 in postmortem neocortex samples of AD patients that correlate with higher Aβ42/Aβ40 ratios (Chai et al., 2018). This evidence concerns the gene TOMM70 and Alzheimer disease.