While the exact etiology of AD is unknown, it is biologically characterized by the aggregation of two misfolded proteins: Aβ, the primary component of extracellular plaques, and hyperphosphorylated variants of the microtubule-associated protein tau, which form intracellular inclusions known as neurofibrillary tangles (NFTs) (Knopman et al., 2021). The gene discussed is MAPT; the disease is Alzheimer disease.