HTT and Huntington disease: Using a combination of biochemical and microscopy-based analyses with striatum-derived cell lines and murine models of HD, Friedlander and colleagues found that Htt and mHtt (and N-terminal fragments thereof) interact directly with the mitochondrial TIM23 complex and are localized to the IMS (Yano et al., 2014; Yablonska et al., 2019) (Figure 10C).