PITX2 and atrial fibrillation: Most of the common genetic variants associated with AF are located within or close to the paired-like homeodomain 2 (PITX2) gene on chromosome 4q25 (Bapat et al., 2018; Roselli et al., 2020); and both under- and overexpression levels of PITX2c have been found in AF patients, regardless of specific mutations (Chinchilla et al., 2011; Pérez-Hernández et al., 2016; Syeda et al., 2017).