Hong et al. (2022) have shown that exosomal miR-20b-5p and miR-106a-5p can reduce adipocyte differentiation in a PCOS mouse model with IR, thereby alleviating lipid metabolism disorders in the pathogenesis of PCOS caused by IR. Katayama et al. (2019) reported that miR-20b-5p can regulate insulin-mediated glucose metabolism through PKB/Akt signaling to play an intracellular role. Here, INS is linked to polycystic ovary syndrome.