In D. melanogaster models of autophagy, particularly those expressing the 2N4R-Tau, and in neuroblastoma cells, the downstream effects of the insulin receptor signaling cascade lead to tau hyperphosphorylation at AT8 and PHF1 (PHD finger protein 1) residues (Goncalves et al., 2019). The gene discussed is MAPT; the disease is neuroblastoma.