TNF and early-onset autosomal dominant Alzheimer disease: Through GSEA, we also found that only “protein processing in endoplasmic reticulum (NES = 4.52)” and “Alzheimer’s disease (NES = 1.93)” were positively enriched, while “insulin signaling pathway (NES = −2.62),” “AMPK signaling pathway (NES = −2.43),” “Toll-like receptor signaling pathway (NES = −2.42),” “TNF signaling pathway (NES = −2.37),” and “FoxO signaling pathway (NES = −2.29)” were negatively enriched (Figure 5; Supplementary Table S4).