In humans, uPAR is encoded by PLAUR on chromosome 19q13, comprising 52 amino acids at the N-terminus and 30 amino acids at the C-terminus, which is bounded by glycosyl phosphatidyl inositol anchor.7 The uPAR is cleaved and released from cells as a response to inflammation, producing soluble uPAR (suPAR), which can be considered as a pro-inflammatory marker in T2DM.8 The PA system is composed of uPA and its receptor (uPAR), tissue-type PA (tPA), plasminogen and its multiple receptors as well as three inhibitors (PAI-1, PAI-2, and protease nexin-1(PN-1)). Here, SERPINE2 is linked to type 2 diabetes mellitus.