The deletion of an ATTG in the promoter region of the NFKB1 gene reduced the synthesis of p50.16 Some studies suggest that people with the DD genotype or the rs28362491-D allele have a higher risk of inflammatory diseases such as CVD.13,17,18 Si-Yu Jin et al found that the DD genotype of the NFKB1 gene increased the risk and severity of acute coronary syndrome in the Han population in China.13 The relation between the rs28362491 genotype and CVDs risk factors such as blood glucose, lipid profile, and liver enzymes has been studied less. Here, NFKB1 is linked to acute coronary syndrome.