Osteosarcoma tissues exhibit overexpression of SNHG12, which then leads to an increase in the tumorigenesis and metastasis induced by Notch2-and insulin-like growth factor 1 receptor (IGF1R) through the regulation of miR-195-5p (Zhou et al., 2018; Xu et al., 2020). This evidence concerns the gene SNHG12 and osteosarcoma.