In addition, BCAT1 methylation was found to be associated with obesity (Kaufman et al., 2018), elevated plasma BCAAs for obesity states (She et al., 2007), BCAT1 as a candidate gene associated with obesity (Chen et al., 2013), and obesity associated with type 2 diabetes (Nadler et al., 2000). Here, BCAT1 is linked to obesity due to melanocortin 4 receptor deficiency.