In this study, candidate genes of patients with SLE included TNFSF11, PSTPIP1, TAP1, IL21R, IL10RA, TIRAP, TBK1, IGLL1, LRBA, IL10RB, NCF2, and TCIRG1, while LRBA, IL10RA, TIRAP, TAP1, IL10RB and IL21R have been reported to be associated with the clinical phenotype of SLE (Huang et al., 2004; Webb et al., 2009; Peng et al., 2013; Kara et al., 2019; Liphaus et al., 2020; Tayel et al., 2021). The gene discussed is TIRAP; the disease is systemic lupus erythematosus.