Therefore, we conducted a cMAP analysis, linking the upregulated genes in sepsis with the pathogenic genes related to ROP, and identified ten small molecule compounds (escitalopram, harpagoside, hydroquinidine, latrepirdine, mepyramine, molsidomine, MW-STK33-3B, palonosetron, phenprobamate, and T-0070907) as candidate compounds for potential sepsis treatment. Here, STK33 is linked to Sepsis.